The Institute carries out its research and medical activities in close cooperation with other Russian research institutions.
Russian Academy of Sciences: I.P. Pavlov Research Institute of Physiology; Research Institute of Nuclear Physics; Research Institute of High Molecular Compounds; Research Institute of Gene Biology.

Russian Academy of Medical Sciences (RAMS): Research Institute of Experimental Medicine of the RAMS; D.O. Ott Research Institute of Obstetrics and Gynecologyof the RAMS; Research Institute of Influenza of the RAMS; Research Institute of Medical Primatology of the RAMS; P.K. Anokhin Research Institute of Normal Physiology of the RAMS; Radiological Medical Research Center of the RAMS; N.N. Blokhin Russian Research Center of Oncology of the RAMS.

Higher educational establishments: St. Petersburg State Medical Academy named after I.I. Mechnikov; St. Petersburg State Medical University named after Acad. I.P. Pavlov; St. Petersburg Medical Academy for Post-Graduate Studies; S.M. Kirov Military Medical Academy; Moscow State Medical Dental University; Saratov State Medical University; Chita State Medical Academy; Belarus State Academy for Post-Graduate Studies; Institute of Gerontology of the Ukraine Academy of Medical Sciences.

The Institute is actively involved in introducing the results of research projects into the clinical practice in Europe and rest of the world. The Institute carries out studies on 12 research projects under the agreements on priority research cooperation with 20 countries. The Institute cooperates with a wide range of organizations and institutions.

Non-governmental cooperation has been established between the Institute and the United Nations Organization (UNO) and the International Association of Gerontology and Geriatrics (IAGG). The Institute has been included in the list of research centers, cooperating in the framework of the UN Research Agenda on Ageing for the 21st Century.